C-Dose Research

Overview         Specs         Publications

  1. Pétusseau, AF, Bruza, P, Pogue, BW. Survey of X-ray induced Cherenkov excited fluorophores with potential for human use. J Radiat Res. 2021; :. doi: 10.1093/jrr/rrab055. PubMed PMID:34247250 .
  2. Zhu, TC, Ong, Y, Sun, H, Zhong, W, Miao, T, Dimofte, A et al.. Cherenkov imaging for Total Skin Electron Therapy - an evaluation of dose uniformity. Proc SPIE Int Soc Opt Eng. 2021;11628 :. doi: 10.1117/12.2583939. PubMed PMID:34083857 PubMed Central PMC8171222.
  3. Hachadorian, R, Farwell, JC, Bruza, P, Jermyn, M, Gladstone, DJ, Pogue, BW et al.. Verification of field match lines in whole breast radiation therapy using Cherenkov imaging. Radiother Oncol. 2021;160 :90-96. doi: 10.1016/j.radonc.2021.04.013. PubMed PMID:33892022 .
  4. Alexander, DA, Bruza, P, Rassias, AG, Andreozzi, JM, Pogue, BW, Zhang, R et al.. Visual Isocenter Position Enhanced Review (VIPER): a Cherenkov imaging-based solution for MR-linac daily QA. Med Phys. 2021;48 (6):2750-2759. doi: 10.1002/mp.14892. PubMed PMID:33887796 PubMed Central PMC8273102.
  5. Cao, X, Gunn, JR, Allu, SR, Bruza, P, Jiang, S, Vinogradov, SA et al.. Implantable sensor for local Cherenkov-excited luminescence imaging of tumor pO2 during radiotherapy. J Biomed Opt. 2020;25 (11):. doi: 10.1117/1.JBO.25.11.112704. PubMed PMID:33236619 PubMed Central PMC7685386.
  6. Jarvis, LA, Hachadorian, RL, Jermyn, M, Bruza, P, Alexander, DA, Tendler, II et al.. Initial Clinical Experience of Cherenkov Imaging in External Beam Radiation Therapy Identifies Opportunities to Improve Treatment Delivery. Int J Radiat Oncol Biol Phys. 2021;109 (5):1627-1637. doi: 10.1016/j.ijrobp.2020.11.013. PubMed PMID:33227443 .
  7. Cao, X, Jiang, S, Gunn, JR, Bruza, P, Pogue, BW. Single pixel hyperspectral Cherenkov-excited fluorescence imaging with LINAC X-ray sheet scanning and spectral unmixing. Opt Lett. 2020;45 (22):6130-6133. doi: 10.1364/OL.401286. PubMed PMID:33186932 .
  8. LaRochelle, EPM, Pogue, BW. Theoretical lateral and axial sensitivity limits and choices of molecular reporters for Cherenkov-excited luminescence in tissue during x-ray beam scanning. J Biomed Opt. 2020;25 (11):. doi: 10.1117/1.JBO.25.11.116004. PubMed PMID:33185051 PubMed Central PMC7658603.
  9. Alexander, DA, Bruza, P, Farwell, JCM, Krishnaswamy, V, Zhang, R, Gladstone, DJ et al.. Detective quantum efficiency of intensified CMOS cameras for Cherenkov imaging in radiotherapy. Phys Med Biol. 2020;65 (22):225013. doi: 10.1088/1361-6560/abb0c5. PubMed PMID:33179612 .
  10. Yao, C, Li, J, Cao, X, Gunn, JR, Wu, M, Jiang, S et al.. X-ray-Induced Cherenkov Optical Triggering of Caged Doxorubicin Released to the Nucleus for Chemoradiation Activation. ACS Appl Mater Interfaces. 2020;12 (40):44383-44392. doi: 10.1021/acsami.0c05189. PubMed PMID:32914957 .
  11. Alexander, DA, Zhang, R, Brůža, P, Pogue, BW, Gladstone, DJ. Scintillation imaging as a high-resolution, remote, versatile 2D detection system for MR-linac quality assurance. Med Phys. 2020;47 (9):3861-3869. doi: 10.1002/mp.14353. PubMed PMID:32583484 .
  12. Miao, T, Petroccia, H, Xie, Y, Jermyn, M, Perroni-Scharf, M, Kapoor, N et al.. Computer animation body surface analysis of total skin electron radiation therapy dose homogeneity via Cherenkov imaging. J Med Imaging (Bellingham). 2020;7 (3):034002. doi: 10.1117/1.JMI.7.3.034002. PubMed PMID:32509916 PubMed Central PMC7267842.
  13. Rahman, M, Brůža, P, Langen, KM, Gladstone, DJ, Cao, X, Pogue, BW et al.. Characterization of a new scintillation imaging system for proton pencil beam dose rate measurements. Phys Med Biol. 2020;65 (16):165014. doi: 10.1088/1361-6560/ab9452. PubMed PMID:32428888 .
  14. Hachadorian, RL, Bruza, P, Jermyn, M, Gladstone, DJ, Pogue, BW, Jarvis, LA et al.. Imaging radiation dose in breast radiotherapy by X-ray CT calibration of Cherenkov light. Nat Commun. 2020;11 (1):2298. doi: 10.1038/s41467-020-16031-z. PubMed PMID:32385233 PubMed Central PMC7210272.
  15. Soter, JA, LaRochelle, EPM, Byrd, BK, Tendler, II, Gunn, JR, Meng, B et al.. Tracking tumor radiotherapy response in vivo with Cherenkov-excited luminescence ink imaging. Phys Med Biol. 2020;65 (9):095004. doi: 10.1088/1361-6560/ab7d16. PubMed PMID:32135522 PubMed Central PMC7190437.
  16. Cao, X, Rao Allu, S, Jiang, S, Jia, M, Gunn, JR, Yao, C et al.. Tissue pO2 distributions in xenograft tumors dynamically imaged by Cherenkov-excited phosphorescence during fractionated radiation therapy. Nat Commun. 2020;11 (1):573. doi: 10.1038/s41467-020-14415-9. PubMed PMID:31996677 PubMed Central PMC6989492.
  17. Tendler, II, Hartford, A, Jermyn, M, LaRochelle, E, Cao, X, Borza, V et al.. Experimentally Observed Cherenkov Light Generation in the Eye During Radiation Therapy. Int J Radiat Oncol Biol Phys. 2020;106 (2):422-429. doi: 10.1016/j.ijrobp.2019.10.031. PubMed PMID:31669563 PubMed Central PMC7161418.
  18. Xie, Y, Petroccia, H, Maity, A, Miao, T, Zhu, Y, Bruza, P et al.. Cherenkov imaging for total skin electron therapy (TSET). Med Phys. 2020;47 (1):201-212. doi: 10.1002/mp.13881. PubMed PMID:31665544 PubMed Central PMC7050296.
  19. Brůža, P, Pétusseau, A, Tisa, S, Jermyn, M, Jarvis, LA, Gladstone, DJ et al.. Imaging Cherenkov photon emissions in radiotherapy with a Geiger-mode gated quanta image sensor. Opt Lett. 2019;44 (18):4546-4549. doi: 10.1364/OL.44.004546. PubMed PMID:31517927 PubMed Central PMC7181332.
  20. Tendler, II, Bruza, P, Jermyn, M, Fleury, A, Williams, BB, Jarvis, LA et al.. Improvements to an optical scintillator imaging-based tissue dosimetry system. J Biomed Opt. 2019;24 (7):1-6. doi: 10.1117/1.JBO.24.7.075001. PubMed PMID:31313537 PubMed Central PMC6630097.
  21. Alexander, DA, Tendler, II, Bruza, P, Cao, X, Schaner, PE, Marshall, BS et al.. Assessment of imaging Cherenkov and scintillation signals in head and neck radiotherapy. Phys Med Biol. 2019;64 (14):145021. doi: 10.1088/1361-6560/ab25a3. PubMed PMID:31146269 PubMed Central PMC7123963.
  22. Tendler, II, Bruza, P, Jermyn, M, Cao, X, Williams, BB, Jarvis, LA et al.. Characterization of a non-contact imaging scintillator-based dosimetry system for total skin electron therapy. Phys Med Biol. 2019;64 (12):125025. doi: 10.1088/1361-6560/ab1d8a. PubMed PMID:31035267 .
  23. Jia, MJ, Bruza, P, Andreozzi, JM, Jarvis, LA, Gladstone, DJ, Pogue, BW et al.. Cherenkov-excited luminescence scanned imaging using scanned beam differencing and iterative deconvolution in dynamic plan radiation delivery in a human breast phantom geometry. Med Phys. 2019;46 (7):3067-3077. doi: 10.1002/mp.13545. PubMed PMID:30980725 PubMed Central PMC7189122.
  24. Jia, MJ, Cao, X, Gunn, JR, Bruza, P, Jiang, S, Pogue, BW et al.. Tomographic Cherenkov-excited luminescence scanned imaging with multiple pinhole beams recovered via back-projection reconstruction. Opt Lett. 2019;44 (7):1552-1555. doi: 10.1364/OL.44.001552. PubMed PMID:30933088 PubMed Central PMC7104332.
  25. Pogue, BW, Feng, J, LaRochelle, EP, Bruža, P, Lin, H, Zhang, R et al.. Maps of in vivo oxygen pressure with submillimetre resolution and nanomolar sensitivity enabled by Cherenkov-excited luminescence scanned imaging. Nat Biomed Eng. 2018;2 (4):254-264. doi: 10.1038/s41551-018-0220-3. PubMed PMID:30899599 PubMed Central PMC6424530.
  26. Jia, MJ, Bruza, P, Jarvis, LA, Gladstone, DJ, Pogue, BW. Multi-beam scan analysis with a clinical LINAC for high resolution Cherenkov-excited molecular luminescence imaging in tissue. Biomed Opt Express. 2018;9 (9):4217-4234. doi: 10.1364/BOE.9.004217. PubMed PMID:30615721 PubMed Central PMC6157777.
  27. Miao, T, Bruza, P, Pogue, BW, Jermyn, M, Krishnaswamy, V, Ware, W et al.. Cherenkov imaging for linac beam shape analysis as a remote electronic quality assessment verification tool. Med Phys. 2019;46 (2):811-821. doi: 10.1002/mp.13303. PubMed PMID:30471126 PubMed Central PMC6367052.
  28. Cao, X, Jiang, S, Jia, MJ, Gunn, JR, Miao, T, Davis, SC et al.. Cherenkov excited short-wavelength infrared fluorescence imaging in vivo with external beam radiation. J Biomed Opt. 2018;24 (5):1-4. doi: 10.1117/1.JBO.24.5.051405. PubMed PMID:30468044 PubMed Central PMC6250216.
  29. Cao, X, Jiang, S, Jia, M, Gunn, J, Miao, T, Davis, SC et al.. Observation of short wavelength infrared (SWIR) Cherenkov emission. Opt Lett. 2018;43 (16):3854-3857. doi: 10.1364/OL.43.003854. PubMed PMID:30106900 PubMed Central PMC7577552.
  30. Andreozzi, JM, Mooney, KE, Brůža, P, Curcuru, A, Gladstone, DJ, Pogue, BW et al.. Remote Cherenkov imaging-based quality assurance of a magnetic resonance image-guided radiotherapy system. Med Phys. 2018;45 (6):2647-2659. doi: 10.1002/mp.12919. PubMed PMID:29663429 .
  31. Andreozzi, JM, Brůža, P, Tendler, II, Mooney, KE, Jarvis, LA, Cammin, J et al.. Improving treatment geometries in total skin electron therapy: Experimental investigation of linac angles and floor scatter dose contributions using Cherenkov imaging. Med Phys. 2018;45 (6):2639-2646. doi: 10.1002/mp.12917. PubMed PMID:29663425 .
  32. Bruza, P, Gollub, SL, Andreozzi, JM, Tendler, II, Williams, BB, Jarvis, LA et al.. Time-gated scintillator imaging for real-time optical surface dosimetry in total skin electron therapy. Phys Med Biol. 2018;63 (9):095009. doi: 10.1088/1361-6560/aaba19. PubMed PMID:29588437 PubMed Central PMC6233889.
  33. Ahmed, SR, Jia, JM, Bruza, P, Vinogradov, S, Jiang, S, Gladstone, DJ et al.. Radiotherapy-induced Cherenkov luminescence imaging in a human body phantom. J Biomed Opt. 2018;23 (3):1-4. doi: 10.1117/1.JBO.23.3.030504. PubMed PMID:29560623 PubMed Central PMC7560997.
  34. LaRochelle, EPM, Shell, JR, Gunn, JR, Davis, SC, Pogue, BW. Signal intensity analysis and optimization for in vivo imaging of Cherenkov and excited luminescence. Phys Med Biol. 2018;63 (8):085019. doi: 10.1088/1361-6560/aab83b. PubMed PMID:29558363 PubMed Central PMC5920648.
  35. Snyder, C, Pogue, BW, Jermyn, M, Tendler, I, Andreozzi, JM, Bruza, P et al.. Algorithm development for intrafraction radiotherapy beam edge verification from Cherenkov imaging. J Med Imaging (Bellingham). 2018;5 (1):015001. doi: 10.1117/1.JMI.5.1.015001. PubMed PMID:29322071 PubMed Central PMC5749647.
  36. Dsouza, A, Lin, H, Gunn, JR, Gladstone, DJ, Jarvis, LA, Pogue, BW et al.. Cherenkov-excited Multi-Fluorophore Sensing in Tissue-Simulating Phantoms and In Vivo from External Beam Radiotherapy. Radiat Res. 2018;189 (2):197-204. doi: 10.1667/RR14943.1. PubMed PMID:29251551 PubMed Central PMC7549019.
  37. Bruza, P, Andreozzi, JM, Gladstone, DJ, Jarvis, LA, Rottmann, J, Pogue, BW et al.. Online Combination of EPID & Cherenkov Imaging for 3-D Dosimetry in a Liquid Phantom. IEEE Trans Med Imaging. 2017;36 (10):2099-2103. doi: 10.1109/TMI.2017.2717800. PubMed PMID:28644800 PubMed Central PMC5659346.
  38. Zhang, R, Glaser, AK, Andreozzi, J, Jiang, S, Jarvis, LA, Gladstone, DJ et al.. Beam and tissue factors affecting Cherenkov image intensity for quantitative entrance and exit dosimetry on human tissue. J Biophotonics. 2017;10 (5):645-656. doi: 10.1002/jbio.201500344. PubMed PMID:27507213 PubMed Central PMC5529250.
  39. Brůža, P, Lin, H, Vinogradov, SA, Jarvis, LA, Gladstone, DJ, Pogue, BW et al.. Light sheet luminescence imaging with Cherenkov excitation in thick scattering media. Opt Lett. 2016;41 (13):2986-9. doi: 10.1364/OL.41.002986. PubMed PMID:27367082 .
  40. Lin, H, Zhang, R, Gunn, JR, Esipova, TV, Vinogradov, S, Gladstone, DJ et al.. Comparison of Cherenkov excited fluorescence and phosphorescence molecular sensing from tissue with external beam irradiation. Phys Med Biol. 2016;61 (10):3955-68. doi: 10.1088/0031-9155/61/10/3955. PubMed PMID:27120085 .
  41. Andreozzi, JM, Zhang, R, Gladstone, DJ, Williams, BB, Glaser, AK, Pogue, BW et al.. Cherenkov imaging method for rapid optimization of clinical treatment geometry in total skin electron beam therapy. Med Phys. 2016;43 (2):993-1002. doi: 10.1118/1.4939880. PubMed PMID:26843259 PubMed Central PMC4744235.
  42. Darafsheh, A, Zhang, R, Kanick, SC, Pogue, BW, Finlay, JC. Spectroscopic separation of Čerenkov radiation in high-resolution radiation fiber dosimeters. J Biomed Opt. 2015;20 (9):095001. doi: 10.1117/1.JBO.20.9.095001. PubMed PMID:26334972 .
  43. Tanha, K, Pashazadeh, AM, Pogue, BW. Review of biomedical Čerenkov luminescence imaging applications. Biomed Opt Express. 2015;6 (8):3053-65. doi: 10.1364/BOE.6.003053. PubMed PMID:26309766 PubMed Central PMC4541530.
  44. Glaser, AK, Zhang, R, Andreozzi, JM, Gladstone, DJ, Pogue, BW. Cherenkov radiation fluence estimates in tissue for molecular imaging and therapy applications. Phys Med Biol. 2015;60 (17):6701-18. doi: 10.1088/0031-9155/60/17/6701. PubMed PMID:26270125 PubMed Central PMC5145313.
  45. Glaser, AK, Andreozzi, JM, Zhang, R, Pogue, BW, Gladstone, DJ. Optical cone beam tomography of Cherenkov-mediated signals for fast 3D dosimetry of x-ray photon beams in water. Med Phys. 2015;42 (7):4127-36. doi: 10.1118/1.4922135. PubMed PMID:26133613 PubMed Central PMC4474948.
  46. Zhang, R, D'souza, AV, Gunn, JR, Esipova, TV, Vinogradov, SA, Glaser, AK et al.. Cherenkov-excited luminescence scanned imaging. Opt Lett. 2015;40 (5):827-30. doi: 10.1364/OL.40.000827. PubMed PMID:25723443 .
  47. Andreozzi, JM, Zhang, R, Glaser, AK, Jarvis, LA, Pogue, BW, Gladstone, DJ et al.. Camera selection for real-time in vivo radiation treatment verification systems using Cherenkov imaging. Med Phys. 2015;42 (2):994-1004. doi: 10.1118/1.4906249. PubMed PMID:25652512 PubMed Central PMC4312350.
  48. Holt, RW, Zhang, R, Esipova, TV, Vinogradov, SA, Glaser, AK, Gladstone, DJ et al.. Cherenkov excited phosphorescence-based pO2 estimation during multi-beam radiation therapy: phantom and simulation studies. Phys Med Biol. 2014;59 (18):5317-5328. doi: 10.1088/0031-9155/59/18/5317. PubMed PMID:25146556 PubMed Central PMC4259158.
  49. Glaser, AK, Zhang, R, Gladstone, DJ, Pogue, BW. Optical dosimetry of radiotherapy beams using Cherenkov radiation: the relationship between light emission and dose. Phys Med Biol. 2014;59 (14):3789-811. doi: 10.1088/0031-9155/59/14/3789. PubMed PMID:24938928 .
  50. Glaser, AK, Andreozzi, JM, Davis, SC, Zhang, R, Pogue, BW, Fox, CJ et al.. Video-rate optical dosimetry and dynamic visualization of IMRT and VMAT treatment plans in water using Cherenkov radiation. Med Phys. 2014;41 (6):062102. doi: 10.1118/1.4875704. PubMed PMID:24877829 PubMed Central PMC4032443.
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