C-Dose Research
- Cao, X, Gunn, JR, Allu, SR, Bruza, P, Jiang, S, Vinogradov, SA et al.. Implantable sensor for local Cherenkov-excited luminescence imaging of tumor pO2 during radiotherapy. J Biomed Opt. 2020;25 (11):. doi: 10.1117/1.JBO.25.11.112704. PubMed PMID:33236619 PubMed Central PMC7685386.
- Jarvis, LA, Hachadorian, RL, Jermyn, M, Bruza, P, Alexander, DA, Tendler, II et al.. Initial Clinical Experience of Cherenkov Imaging in External Beam Radiation Therapy Identifies Opportunities to Improve Treatment Delivery. Int J Radiat Oncol Biol Phys. 2020; :. doi: 10.1016/j.ijrobp.2020.11.013. PubMed PMID:33227443 .
- Cao, X, Jiang, S, Gunn, JR, Bruza, P, Pogue, BW. Single pixel hyperspectral Cherenkov-excited fluorescence imaging with LINAC X-ray sheet scanning and spectral unmixing. Opt Lett. 2020;45 (22):6130-6133. doi: 10.1364/OL.401286. PubMed PMID:33186932 .
- LaRochelle, EPM, Pogue, BW. Theoretical lateral and axial sensitivity limits and choices of molecular reporters for Cherenkov-excited luminescence in tissue during x-ray beam scanning. J Biomed Opt. 2020;25 (11):. doi: 10.1117/1.JBO.25.11.116004. PubMed PMID:33185051 PubMed Central PMC7658603.
- Alexander, DA, Bruza, P, Farwell, JCM, Krishnaswamy, V, Zhang, R, Gladstone, DJ et al.. Detective quantum efficiency of intensified CMOS cameras for Cherenkov imaging in radiotherapy. Phys Med Biol. 2020;65 (22):225013. doi: 10.1088/1361-6560/abb0c5. PubMed PMID:33179612 .
- Yao, C, Li, J, Cao, X, Gunn, JR, Wu, M, Jiang, S et al.. X-ray-Induced Cherenkov Optical Triggering of Caged Doxorubicin Released to the Nucleus for Chemoradiation Activation. ACS Appl Mater Interfaces. 2020;12 (40):44383-44392. doi: 10.1021/acsami.0c05189. PubMed PMID:32914957 .
- Alexander, DA, Zhang, R, Brůža, P, Pogue, BW, Gladstone, DJ. Scintillation imaging as a high-resolution, remote, versatile 2D detection system for MR-linac quality assurance. Med Phys. 2020;47 (9):3861-3869. doi: 10.1002/mp.14353. PubMed PMID:32583484 .
- Miao, T, Petroccia, H, Xie, Y, Jermyn, M, Perroni-Scharf, M, Kapoor, N et al.. Computer animation body surface analysis of total skin electron radiation therapy dose homogeneity via Cherenkov imaging. J Med Imaging (Bellingham). 2020;7 (3):034002. doi: 10.1117/1.JMI.7.3.034002. PubMed PMID:32509916 PubMed Central PMC7267842.
- Rahman, M, Brůža, P, Langen, KM, Gladstone, DJ, Cao, X, Pogue, BW et al.. Characterization of a new scintillation imaging system for proton pencil beam dose rate measurements. Phys Med Biol. 2020;65 (16):165014. doi: 10.1088/1361-6560/ab9452. PubMed PMID:32428888 .
- Hachadorian, RL, Bruza, P, Jermyn, M, Gladstone, DJ, Pogue, BW, Jarvis, LA et al.. Imaging radiation dose in breast radiotherapy by X-ray CT calibration of Cherenkov light. Nat Commun. 2020;11 (1):2298. doi: 10.1038/s41467-020-16031-z. PubMed PMID:32385233 PubMed Central PMC7210272.
- Soter, JA, LaRochelle, EPM, Byrd, BK, Tendler, II, Gunn, JR, Meng, B et al.. Tracking tumor radiotherapy response in vivo with Cherenkov-excited luminescence ink imaging. Phys Med Biol. 2020;65 (9):095004. doi: 10.1088/1361-6560/ab7d16. PubMed PMID:32135522 PubMed Central PMC7190437.
- Cao, X, Rao Allu, S, Jiang, S, Jia, M, Gunn, JR, Yao, C et al.. Tissue pO2 distributions in xenograft tumors dynamically imaged by Cherenkov-excited phosphorescence during fractionated radiation therapy. Nat Commun. 2020;11 (1):573. doi: 10.1038/s41467-020-14415-9. PubMed PMID:31996677 PubMed Central PMC6989492.
- Tendler, II, Hartford, A, Jermyn, M, LaRochelle, E, Cao, X, Borza, V et al.. Experimentally Observed Cherenkov Light Generation in the Eye During Radiation Therapy. Int J Radiat Oncol Biol Phys. 2020;106 (2):422-429. doi: 10.1016/j.ijrobp.2019.10.031. PubMed PMID:31669563 PubMed Central PMC7161418.
- Xie, Y, Petroccia, H, Maity, A, Miao, T, Zhu, Y, Bruza, P et al.. Cherenkov imaging for total skin electron therapy (TSET). Med Phys. 2020;47 (1):201-212. doi: 10.1002/mp.13881. PubMed PMID:31665544 PubMed Central PMC7050296.
- Brůža, P, Pétusseau, A, Tisa, S, Jermyn, M, Jarvis, LA, Gladstone, DJ et al.. Imaging Cherenkov photon emissions in radiotherapy with a Geiger-mode gated quanta image sensor. Opt Lett. 2019;44 (18):4546-4549. doi: 10.1364/OL.44.004546. PubMed PMID:31517927 PubMed Central PMC7181332.
- Tendler, II, Bruza, P, Jermyn, M, Fleury, A, Williams, BB, Jarvis, LA et al.. Improvements to an optical scintillator imaging-based tissue dosimetry system. J Biomed Opt. 2019;24 (7):1-6. doi: 10.1117/1.JBO.24.7.075001. PubMed PMID:31313537 PubMed Central PMC6630097.
- Alexander, DA, Tendler, II, Bruza, P, Cao, X, Schaner, PE, Marshall, BS et al.. Assessment of imaging Cherenkov and scintillation signals in head and neck radiotherapy. Phys Med Biol. 2019;64 (14):145021. doi: 10.1088/1361-6560/ab25a3. PubMed PMID:31146269 PubMed Central PMC7123963.
- Tendler, II, Bruza, P, Jermyn, M, Cao, X, Williams, BB, Jarvis, LA et al.. Characterization of a non-contact imaging scintillator-based dosimetry system for total skin electron therapy. Phys Med Biol. 2019;64 (12):125025. doi: 10.1088/1361-6560/ab1d8a. PubMed PMID:31035267 .
- Jia, MJ, Bruza, P, Andreozzi, JM, Jarvis, LA, Gladstone, DJ, Pogue, BW et al.. Cherenkov-excited luminescence scanned imaging using scanned beam differencing and iterative deconvolution in dynamic plan radiation delivery in a human breast phantom geometry. Med Phys. 2019;46 (7):3067-3077. doi: 10.1002/mp.13545. PubMed PMID:30980725 PubMed Central PMC7189122.
- Jia, MJ, Cao, X, Gunn, JR, Bruza, P, Jiang, S, Pogue, BW et al.. Tomographic Cherenkov-excited luminescence scanned imaging with multiple pinhole beams recovered via back-projection reconstruction. Opt Lett. 2019;44 (7):1552-1555. doi: 10.1364/OL.44.001552. PubMed PMID:30933088 PubMed Central PMC7104332.
- Pogue, BW, Feng, J, LaRochelle, EP, Bruža, P, Lin, H, Zhang, R et al.. Maps of in vivo oxygen pressure with submillimetre resolution and nanomolar sensitivity enabled by Cherenkov-excited luminescence scanned imaging. Nat Biomed Eng. 2018;2 (4):254-264. doi: 10.1038/s41551-018-0220-3. PubMed PMID:30899599 PubMed Central PMC6424530.
- Jia, MJ, Bruza, P, Jarvis, LA, Gladstone, DJ, Pogue, BW. Multi-beam scan analysis with a clinical LINAC for high resolution Cherenkov-excited molecular luminescence imaging in tissue. Biomed Opt Express. 2018;9 (9):4217-4234. doi: 10.1364/BOE.9.004217. PubMed PMID:30615721 PubMed Central PMC6157777.
- Miao, T, Bruza, P, Pogue, BW, Jermyn, M, Krishnaswamy, V, Ware, W et al.. Cherenkov imaging for linac beam shape analysis as a remote electronic quality assessment verification tool. Med Phys. 2019;46 (2):811-821. doi: 10.1002/mp.13303. PubMed PMID:30471126 PubMed Central PMC6367052.
- Cao, X, Jiang, S, Jia, MJ, Gunn, JR, Miao, T, Davis, SC et al.. Cherenkov excited short-wavelength infrared fluorescence imaging in vivo with external beam radiation. J Biomed Opt. 2018;24 (5):1-4. doi: 10.1117/1.JBO.24.5.051405. PubMed PMID:30468044 PubMed Central PMC6250216.
- Cao, X, Jiang, S, Jia, M, Gunn, J, Miao, T, Davis, SC et al.. Observation of short wavelength infrared (SWIR) Cherenkov emission. Opt Lett. 2018;43 (16):3854-3857. doi: 10.1364/OL.43.003854. PubMed PMID:30106900 PubMed Central PMC7577552.
- Andreozzi, JM, Mooney, KE, Brůža, P, Curcuru, A, Gladstone, DJ, Pogue, BW et al.. Remote Cherenkov imaging-based quality assurance of a magnetic resonance image-guided radiotherapy system. Med Phys. 2018;45 (6):2647-2659. doi: 10.1002/mp.12919. PubMed PMID:29663429 .
- Andreozzi, JM, Brůža, P, Tendler, II, Mooney, KE, Jarvis, LA, Cammin, J et al.. Improving treatment geometries in total skin electron therapy: Experimental investigation of linac angles and floor scatter dose contributions using Cherenkov imaging. Med Phys. 2018;45 (6):2639-2646. doi: 10.1002/mp.12917. PubMed PMID:29663425 .
- Bruza, P, Gollub, SL, Andreozzi, JM, Tendler, II, Williams, BB, Jarvis, LA et al.. Time-gated scintillator imaging for real-time optical surface dosimetry in total skin electron therapy. Phys Med Biol. 2018;63 (9):095009. doi: 10.1088/1361-6560/aaba19. PubMed PMID:29588437 PubMed Central PMC6233889.
- Ahmed, SR, Jia, JM, Bruza, P, Vinogradov, S, Jiang, S, Gladstone, DJ et al.. Radiotherapy-induced Cherenkov luminescence imaging in a human body phantom. J Biomed Opt. 2018;23 (3):1-4. doi: 10.1117/1.JBO.23.3.030504. PubMed PMID:29560623 PubMed Central PMC7560997.
- LaRochelle, EPM, Shell, JR, Gunn, JR, Davis, SC, Pogue, BW. Signal intensity analysis and optimization for in vivo imaging of Cherenkov and excited luminescence. Phys Med Biol. 2018;63 (8):085019. doi: 10.1088/1361-6560/aab83b. PubMed PMID:29558363 PubMed Central PMC5920648.
- Snyder, C, Pogue, BW, Jermyn, M, Tendler, I, Andreozzi, JM, Bruza, P et al.. Algorithm development for intrafraction radiotherapy beam edge verification from Cherenkov imaging. J Med Imaging (Bellingham). 2018;5 (1):015001. doi: 10.1117/1.JMI.5.1.015001. PubMed PMID:29322071 PubMed Central PMC5749647.
- Dsouza, A, Lin, H, Gunn, JR, Gladstone, DJ, Jarvis, LA, Pogue, BW et al.. Cherenkov-excited Multi-Fluorophore Sensing in Tissue-Simulating Phantoms and In Vivo from External Beam Radiotherapy. Radiat Res. 2018;189 (2):197-204. doi: 10.1667/RR14943.1. PubMed PMID:29251551 PubMed Central PMC7549019.
- Bruza, P, Andreozzi, JM, Gladstone, DJ, Jarvis, LA, Rottmann, J, Pogue, BW et al.. Online Combination of EPID & Cherenkov Imaging for 3-D Dosimetry in a Liquid Phantom. IEEE Trans Med Imaging. 2017;36 (10):2099-2103. doi: 10.1109/TMI.2017.2717800. PubMed PMID:28644800 PubMed Central PMC5659346.
- Zhang, R, Glaser, AK, Andreozzi, J, Jiang, S, Jarvis, LA, Gladstone, DJ et al.. Beam and tissue factors affecting Cherenkov image intensity for quantitative entrance and exit dosimetry on human tissue. J Biophotonics. 2017;10 (5):645-656. doi: 10.1002/jbio.201500344. PubMed PMID:27507213 PubMed Central PMC5529250.
- Brůža, P, Lin, H, Vinogradov, SA, Jarvis, LA, Gladstone, DJ, Pogue, BW et al.. Light sheet luminescence imaging with Cherenkov excitation in thick scattering media. Opt Lett. 2016;41 (13):2986-9. doi: 10.1364/OL.41.002986. PubMed PMID:27367082 .
- Lin, H, Zhang, R, Gunn, JR, Esipova, TV, Vinogradov, S, Gladstone, DJ et al.. Comparison of Cherenkov excited fluorescence and phosphorescence molecular sensing from tissue with external beam irradiation. Phys Med Biol. 2016;61 (10):3955-68. doi: 10.1088/0031-9155/61/10/3955. PubMed PMID:27120085 .
- Andreozzi, JM, Zhang, R, Gladstone, DJ, Williams, BB, Glaser, AK, Pogue, BW et al.. Cherenkov imaging method for rapid optimization of clinical treatment geometry in total skin electron beam therapy. Med Phys. 2016;43 (2):993-1002. doi: 10.1118/1.4939880. PubMed PMID:26843259 PubMed Central PMC4744235.
- Darafsheh, A, Zhang, R, Kanick, SC, Pogue, BW, Finlay, JC. Spectroscopic separation of Čerenkov radiation in high-resolution radiation fiber dosimeters. J Biomed Opt. 2015;20 (9):095001. doi: 10.1117/1.JBO.20.9.095001. PubMed PMID:26334972 .
- Tanha, K, Pashazadeh, AM, Pogue, BW. Review of biomedical Čerenkov luminescence imaging applications. Biomed Opt Express. 2015;6 (8):3053-65. doi: 10.1364/BOE.6.003053. PubMed PMID:26309766 PubMed Central PMC4541530.
- Glaser, AK, Zhang, R, Andreozzi, JM, Gladstone, DJ, Pogue, BW. Cherenkov radiation fluence estimates in tissue for molecular imaging and therapy applications. Phys Med Biol. 2015;60 (17):6701-18. doi: 10.1088/0031-9155/60/17/6701. PubMed PMID:26270125 PubMed Central PMC5145313.
- Glaser, AK, Andreozzi, JM, Zhang, R, Pogue, BW, Gladstone, DJ. Optical cone beam tomography of Cherenkov-mediated signals for fast 3D dosimetry of x-ray photon beams in water. Med Phys. 2015;42 (7):4127-36. doi: 10.1118/1.4922135. PubMed PMID:26133613 PubMed Central PMC4474948.
- Zhang, R, D'souza, AV, Gunn, JR, Esipova, TV, Vinogradov, SA, Glaser, AK et al.. Cherenkov-excited luminescence scanned imaging. Opt Lett. 2015;40 (5):827-30. doi: 10.1364/OL.40.000827. PubMed PMID:25723443 .
- Andreozzi, JM, Zhang, R, Glaser, AK, Jarvis, LA, Pogue, BW, Gladstone, DJ et al.. Camera selection for real-time in vivo radiation treatment verification systems using Cherenkov imaging. Med Phys. 2015;42 (2):994-1004. doi: 10.1118/1.4906249. PubMed PMID:25652512 PubMed Central PMC4312350.
- Holt, RW, Zhang, R, Esipova, TV, Vinogradov, SA, Glaser, AK, Gladstone, DJ et al.. Cherenkov excited phosphorescence-based pO2 estimation during multi-beam radiation therapy: phantom and simulation studies. Phys Med Biol. 2014;59 (18):5317-5328. doi: 10.1088/0031-9155/59/18/5317. PubMed PMID:25146556 PubMed Central PMC4259158.
- Glaser, AK, Zhang, R, Gladstone, DJ, Pogue, BW. Optical dosimetry of radiotherapy beams using Cherenkov radiation: the relationship between light emission and dose. Phys Med Biol. 2014;59 (14):3789-811. doi: 10.1088/0031-9155/59/14/3789. PubMed PMID:24938928 .
- Glaser, AK, Andreozzi, JM, Davis, SC, Zhang, R, Pogue, BW, Fox, CJ et al.. Video-rate optical dosimetry and dynamic visualization of IMRT and VMAT treatment plans in water using Cherenkov radiation. Med Phys. 2014;41 (6):062102. doi: 10.1118/1.4875704. PubMed PMID:24877829 PubMed Central PMC4032443.
- Jarvis, LA, Zhang, R, Gladstone, DJ, Jiang, S, Hitchcock, W, Friedman, OD et al.. Cherenkov video imaging allows for the first visualization of radiation therapy in real time. Int J Radiat Oncol Biol Phys. 2014;89 (3):615-22. doi: 10.1016/j.ijrobp.2014.01.046. PubMed PMID:24685442 .
- Zhang, R, Glaser, AK, Gladstone, DJ, Fox, CJ, Pogue, BW. Superficial dosimetry imaging based on Čerenkov emission for external beam radiotherapy with megavoltage x-ray beam. Med Phys. 2013;40 (10):101914. doi: 10.1118/1.4821543. PubMed PMID:24089916 PubMed Central PMC3790817.
- Zhang, R, Fox, CJ, Glaser, AK, Gladstone, DJ, Pogue, BW. Superficial dosimetry imaging of Čerenkov emission in electron beam radiotherapy of phantoms. Phys Med Biol. 2013;58 (16):5477-93. doi: 10.1088/0031-9155/58/16/5477. PubMed PMID:23880473 PubMed Central PMC4143764.
- Zhang, R, Davis, SC, Demers, JL, Glaser, AK, Gladstone, DJ, Esipova, TV et al.. Oxygen tomography by Čerenkov-excited phosphorescence during external beam irradiation. J Biomed Opt. 2013;18 (5):50503. doi: 10.1117/1.JBO.18.5.050503. PubMed PMID:23644902 PubMed Central PMC3643897.